DETAILED NOTES ON LIMITED EDITION EXCLUSIVE LSD CRYSTAL)

Within the LSD-certain crystal framework, the aspect chain on the lid residue L209EL2 kinds in depth hydrophobic contacts with each LSD and encompassing residues in TMs III, IV, and V (Determine 4C). If the lid moved aside to expose the binding pocket in simulation, several of such contacts broke. We thus hypothesized that L209EL2 functions for a l